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KMID : 0356920080540060662
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Korean Journal of Anesthesiology
2008 Volume.54 No. 6 p.662 ~ p.668
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Effects of Propofol on Arginine Vasopressin-induced Contraction in Isolated Human Gastroepiploic Artery
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Lee Seong-Jin
Baik Seong-Wan
Cho Hyeok-Rae
Kim Won-Sung
Baek Seung-Hoon
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Abstract
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Background: Arginine vasopressin has been used by prophylactic treatment of vasodilatory shock during coronary artery bypass graft (CABG). Vasopressin may be a cause of spasm in graft artery during CABG. We evaluated the effect of propofol on vasopressin-induced contraction in human gastroepiploic artery (GEA).
Methods: Human GEA were obtained from 35 patients (43?74 yr), undergoing subtotal gastrectomy. Vasopressin-induced a concentration contractions (10?9 to 10?6 M) were measured after exposed to without propofol, propofol 10?5, 10?4, 10?3 M. After endothelium denuding vasopressin-induced a concentration contractions were measured with or without propofol 10?3 M in calcium free solution. In the denuded vascular rings, with or without pretreatment of glibenclamide (10?5 M), nicorandil (10?5 M), or diltiazem (10?5 M) were exposed to with or without propofol 10?3 M, and vasopressin-induced concentration contractions were measured.
Results: Vasopressin-induced concentration contraction on human GEA was independent of functional endothelium. Propofol (10?4, 10?3 M) attenuated the vasopressin-induced contraction in the human GEA. Diltiazem attenuated the vasopressin-induced contraction in the human GEA. ATP-sensitive potassium channel does not affect the inhibition effect of propofol on vasopressin-induced contraction
Conclusions: Usual anesthetic dose of propofol does not inhibit vasopressin-induced contraction on human GEA. High dose (＞10?4 M) propofol attenuated vasopresssi-induced contraction on GEA.
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KEYWORD
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coronary artery bypass grafting, propofol, vasopressin
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